Oxytocin
Oxytocin
Description
A hypothalamic neuropeptide involved in social bonding, reproduction, and stress regulation. Known as the "love hormone."
Overview
Oxytocin is a hormone and neuropeptide with roles in childbirth, lactation, social bonding, and pain modulation. Research delivery routes include subcutaneous injection, intranasal spray, and sublingual ODTs.
Mechanism of Action
Oxytocin is a neuropeptide implicated in social behavior that also exerts antinociceptive (pain-reducing) effects. Subcutaneous oxytocin has been shown to reduce heat-pain intensity and unpleasantness ratings locally on the injected arm, suggesting a peripheral mechanism in addition to its central actions.
Benefits
- •Social bonding
- •Stress reduction
- •Mood enhancement
- •Reproductive function
- •Anxiety reduction
- •Trust enhancement
Dosing Notes
Studies have used SQ synthetic oxytocin at 4 mcg/2 mL. Intranasal regimens range from single 24-48 IU doses to 24-48 IU daily for two weeks. Sublingual ODTs are commonly 10-100 IU dissolved ~30 minutes before sexual activity.
Reported Side Effects
- •Nausea
- •Headache
- •Flushing
- •Mood changes
- •Uterine contraction (in pregnancy)
- •Hyponatremia with high doses
Safety Notes
Oxytocin is excreted in breast milk but is not expected to harm infants. Do not use during pregnancy as oxytocin induces uterine contractions.