NAD+
Nicotinamide Adenine Dinucleotide
Description
A coenzyme essential for cellular energy production and DNA repair. Declines with age, making supplementation relevant for longevity.
Overview
NAD+ is used by cells to produce energy, repair DNA, and maintain health. Levels decline with age. Therapies aim to deliver NAD+ or its precursors (NMN, NR, niacinamide) systemically, with limits on how much circulating administration raises intracellular levels.
Mechanism of Action
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme central to energy metabolism and cellular maintenance. It participates in redox reactions that drive ATP production, supports key metabolic enzymes, and is consumed by DNA-repair and sirtuin enzymes.
Benefits
- •Cellular energy
- •DNA repair
- •Longevity
- •Anti-aging
- •Metabolic health
- •Mitochondrial function
Dosing Notes
Common reported regimens: oral NMN 250-900 mg 1-2x/day; oral NR 250-500 mg 1-2x/day; IV NAD+ 500-1500 mg per session weekly to monthly; subcutaneous NAD+ 50-200 mg 2-3x/week with site rotation.
Reported Side Effects
- •Injection-site discomfort, erythema, or small nodules
- •Mild fatigue
- •Nausea
- •Headache
Safety Notes
Reported contraindications include known hypersensitivity, severe hepatic or renal impairment, significant cardiovascular or bleeding disorders, and history of cancer. Patients should consult a healthcare provider before starting any new supplement regimen.
Scientific References
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