VIP
Vasoactive Intestinal Peptide
Description
A vasoactive peptide with broad physiological effects including vasodilation, immune modulation, and neuroprotection.
Overview
Vasoactive Intestinal Peptide (VIP) is an endogenous neuropeptide with broad effects on the cardiovascular, GI, immune, and nervous systems. It promotes vasodilation, downregulates Th1/Th17 inflammatory responses, and supports neuroprotection. Clinical and preclinical studies have explored VIP for autoimmune encephalomyelitis, colitis, pulmonary hypertension, and sarcoidosis.
Mechanism of Action
28-amino-acid neuropeptide of the secretin/glucagon family; binds VPAC1 and VPAC2 G-protein-coupled receptors, raising cAMP. Produces vasodilation, smooth muscle relaxation, immune modulation, and anti-inflammatory effects.
Benefits
- •Vasodilation
- •Immune modulation
- •Neuroprotection
- •Anti-inflammatory
- •Sleep regulation
- •Circadian rhythm
Reported Side Effects
- •Hypotension
- •Flushing
- •Tachycardia
- •Headache
- •Injection site reactions
Safety Notes
Rapid degradation limits practical dosing. Hypotensive effects require monitoring. Research use only.