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Kisspeptin-10
Phase 3 TrialsActive clinical research (reproductive endocrinology, hypothalamic amenorrhea, IVF). Not FDA approved as a therapeutic.
Kisspeptin-10
Description
A hypothalamic neuropeptide hormone that triggers puberty onset and regulates reproductive function. Key regulator of GnRH release.
Dose:125 mcg
Frequency:Daily (30 days on, 30 days off cycle)
Administration Method: SQ
CategorySexual Health
Half-LifeApproximately 4 minutes in plasma (rapid degradation by endopeptidases).
Overview
Kisspeptin-10 stimulates GnRH release and is an endogenous GPR54 ligand. A single administration has been reported to boost LH ~2.5-fold and increase testosterone from ~479 ng/dL to ~692 ng/dL within hours.
Mechanism of Action
Kisspeptin-10 is a neuropeptide product of the KISS1 gene, consisting of a conserved C-terminal 10-amino-acid sequence. It binds the G-protein-coupled receptor GPR54, directly stimulating the hypothalamus to release GnRH at the top of the HPG axis.
Benefits
- •Reproductive health
- •Fertility
- •Hormone regulation
- •Puberty regulation
- •Sexual function
Dosing Notes
In PCT contexts, typical dosing is 0.1-0.2 mg SQ 2-3x weekly.
Reported Side Effects
- •Transient flushing
- •Headache
- •Nausea
- •Injection site reactions