What research dose range is reported for SS-31?

Published research literature reports SS-31 amounts of 500 mcg, 5 days on, 2 days off (8 weeks on/off cycle). PepCalcs reports these figures for reference only and does not recommend an amount.

What are the benefits of SS-31?

Mitochondrial protection. Antioxidant. Cellular energy. Heart health. Age-related disease. Muscle function.

How is SS-31 administered?

SS-31 is typically administered via SQ, IV.

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SS-31

Phase 2 TrialsReached Phase 3 trials for primary mitochondrial myopathy. The sponsor's program was disrupted by financial challenges.

SS-31 (Elamipretide)

Description

A mitochondria-targeting antioxidant peptide that protects against oxidative stress. Studied for age-related diseases and cellular energy.

Dose:500 mcg

Frequency:5 days on, 2 days off (8 weeks on/off cycle)

Administration Method: SQ, IV

CategoryLongevity

Half-LifeApproximately 2-5 hours (subcutaneous).

Overview

SS-31 (elamipretide) is a synthetic tetrapeptide developed by Drs. Hazel Szeto and Peter Schiller. It has been studied for cardiac mitochondrial dysfunction, ischemia-reperfusion injury, primary mitochondrial myopathy, and age-related mitochondrial decline.

Mechanism of Action

SS-31 (elamipretide) targets the inner mitochondrial membrane and interacts with cardiolipin, stabilizing the respiratory chain and improving mitochondrial bioenergetics.

Benefits

•Mitochondrial protection
•Antioxidant
•Cellular energy
•Heart health
•Age-related disease
•Muscle function

Dosing Notes

Preclinical mouse studies of cisplatin-induced acute kidney injury used 10 mg/kg/day for 10 days.

Reported Side Effects

•Injection site reactions
•Headache
•Limited long-term human data

Scientific References

PubChem (NIH)Wikipedia

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