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    5-Amino-1MQ

    Phase 1 TrialsPreclinical

    5-Amino-1-Methylquinolinium

    Description

    A small molecule that inhibits NNMT enzyme, boosting NAD+ levels and cellular energy. Supports fat loss and metabolic function.

    Dose:1 mg
    Frequency:5 days on, 2 days off (8 weeks on/off cycle)
    Administration Method: SQ
    CategoryWeight Loss
    Half-LifeApproximately 4-6 hours in plasma.

    Overview

    5-Amino-1MQ, or 5-amino-1-methylquinolinium, is a small molecule discovered in 2017 being researched for fat loss, muscle regeneration, and effects on cancer cells. It inhibits the NNMT enzyme, potentially raising NAD+ and SAM levels involved in energy metabolism and gene regulation. Excess NNMT activity is linked to obesity and metabolic disease. Preclinical work in mice has shown fat loss, improved metabolic markers, and muscle regeneration. It is not approved for human use and remains a research chemical.

    Mechanism of Action

    Inhibits nicotinamide N-methyltransferase (NNMT), increasing NAD+ and SAM availability and altering fat metabolism and muscle regeneration pathways.

    Benefits

    • •Fat loss
    • •Energy boost
    • •NAD+ enhancement
    • •Metabolic support

    Reported Side Effects

    • •Headache
    • •Nausea
    • •Hypoglycemia (theoretical)
    • •Limited human data

    Scientific References

    PubChem (NIH)Wikipedia

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