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    Melanotan 1

    FDA ApprovedFDA approved (as afamelanotide, brand name Scenesse) for erythropoietic protoporphyria.

    Melanotan I

    Description

    An alpha-MSH analogue that stimulates melanogenesis for skin darkening. Provides photoprotection without UV exposure.

    Dose:250 mcg
    Frequency:2 days per week (8 weeks on/off cycle)
    Administration Method: SQ
    CategoryCognitive
    Half-LifeApproximately 30-60 minutes (subcutaneous).

    Overview

    Melanotan 1 is a peptide that increases melanin production in the skin, enabling tanning with lower UV exposure.

    Mechanism of Action

    Melanotan 1 is an analog of alpha-melanocyte-stimulating hormone (α-MSH) that induces skin tanning by stimulating melanogenesis, leading to increased production and secretion of melanin and providing a protective mechanism against UV.

    Benefits

    • •Skin tanning
    • •UV protection
    • •Melanin production
    • •Photoprotection

    Dosing Notes

    A common research protocol injects 0.15 mL once daily for 1-2 weeks, then 0.25 mL twice weekly for maintenance.

    Reported Side Effects

    • •facial flushing
    • •nausea
    • •new or darkened freckles

    Scientific References

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